Sequence homology based protein-protein interacting residue predictions and the applications in ranking docked conformations
نویسندگان
چکیده
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xxiii CHAPTER 1. Overview . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1.1 Experimental Methods to Identify Protein-Protein Interface Residues . . . . . . 2 1.2 Protein-Protein Interface Features . . . . . . . . . . . . . . . . . . . . . . . . . 4 1.3 Computational Methods to Predict Protein-Protein Interface Residues . . . . . 5 1.4 Protein-Protein Docking . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 1.5 Interface Residue Conservation . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 1.6 Hypotheses and Overview of This Work . . . . . . . . . . . . . . . . . . . . . . 9 1.7 Main Contributions of This Work . . . . . . . . . . . . . . . . . . . . . . . . . . 11 CHAPTER 2. Conservation Analysis of Protein-Protein Interface Residues . 13 2.
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